Palladium??Catalyzed C–N Bond Activation: The Synthesis of β??Amino Acid Derivatives from Triethylamine and Acrylates

B Zou, HF Jiang, ZY Wang

Index: Zou, Bo; Jiang, Huan-Feng; Wang, Zhao-Yang European Journal of Organic Chemistry, 2007 , # 27 p. 4600 - 4604

Full Text: HTML

Citation Number: 9

Abstract

Abstract In the palladium-catalyzed reaction of acrylates, C–N bond activation and acetalization occurred under different conditions. Described herein is a highly efficient palladium-catalyzed C–N bond activation reaction and subsequent new C–N bond formation to directly construct β-amino acids from triethylamine and acrylate esters in isolated yields of up to 95%.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, ...

Related Articles:

Efficient copper-catalyzed chemo selective conjugate addition of aliphatic amines to α, β-unsaturated compounds in water

[Xu, Li-Wen; Li, Jing-Wei; Xia, Chun-Gu; Zhou, Shao-Lin; Hu, Xiao-Xue Synlett, 2003 , # 15 p. 2425 - 2427]

Tandem conjugate addition-aldol reaction to α, β-unsaturated esters and ketones using titanium amide

[Hosomi, Akira; Yanagi, Toshiharu; Hojo, Makoto Tetrahedron Letters, 1991 , vol. 32, # 21 p. 2371 - 2374]

The Mechanism of the Cleavage of Ethyl α, α'-Dibromoadipate by Diethylamine

[Fuson; Lundquist Journal of the American Chemical Society, 1938 , vol. 60, p. 1889,1891]

More Articles...