Design and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3β

…, YS Heo, WY Lee, YS Cho, YE Kim, YL Hyun…

Index: Shin, Dongkyu; Lee, Seung-Chul; Heo, Yong-Seok; Lee, Woon-Young; Cho, Yong-Soon; Kim, Yong Eun; Hyun, Young-Lan; Cho, Joong Myung; Lee, Yoon Sup; Ro, Seonggu Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 20 p. 5686 - 5689

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Citation Number: 30

Abstract

A hydroxy functional group was introduced as the hydrogen bond donor and acceptor at the hinge region of protein kinase in order to develop novel ATP-competitive inhibitors. Several derivatives of 7-hydroxyl-1H-benzoimidazole were designed as inhibitors of glycogen synthase kinase-3β with the help of ab initio calculations and a docking study. Enzymatic assay and an X-ray complex study showed that these designed compounds were highly ...

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