Synthesis and SAR of [1, 2, 4] triazolo [1, 5-a] pyrimidines, a class of anticancer agents with a unique mechanism of tubulin inhibition

N Zhang, S Ayral-Kaloustian, T Nguyen…

Index: Journal of Medicinal Chemistry, , vol. 50, # 2 p. 319 - 327

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Citation Number: 110

Abstract

... Journal of Medicinal Chemistry. ... tubulin with a novel mechanism of action. Additional analogues were then prepared to optimize potency and other pharmaceutical properties. Chemistry. Compounds 5−30 and 32−39 ...