Kinetic resolution of aminoalkenes by asymmetric hydroamination: a mechanistic study

AL Reznichenko, F Hampel…

Index: Reznichenko, Alexander L.; Hampel, Frank; Hultzsch, Kai C. Chemistry - A European Journal, 2009 , vol. 15, # 46 p. 12819 - 12827

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Citation Number: 41

Abstract

Abstract The kinetic resolution of chiral aminoalkenes by hydroamination–cyclization was studied by using 3, 3′-bis (triarylsilyl)-substituted binaphtholate rare-earth-metal complexes. The resolution of 1-arylaminopentenes proceeds with high efficiency and high trans-diastereoselectivity, whereas the resolution process of 1-alkylaminopentenes suffers from decreasing resolution efficiency with increasing steric demand of the aliphatic ...