Journal of the American Chemical Society

The synthesis of phosphaisocoumarins by Cu (I)-catalyzed intramolecular cyclization of o-ethynylphenylphosphonic acid monoesters

AY Peng, YX Ding

Index: Peng, Ai-Yun; Ding, Yi-Xiang Journal of the American Chemical Society, 2003 , vol. 125, # 49 p. 15006 - 15007

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Citation Number: 74

Abstract

Cu (I)-catalyzed intramolecular cyclization of o-ethynylphenylphosphonic acid monoethyl esters was examined, and a new class of six-membered phosphorus heterocycles was formed with high regioselectivity and good yields. The present reaction is the first example of intramolecular addition of P-OH to alkynes, which provides a convenient way to synthesize novel phosphorus heterocycles having potential bioactivities.

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