The Journal of Organic Chemistry

Synthesis of phosphonates from. alpha.-hydroxy carbonyl compounds and dialkyl phosphorochloridites

V Roussis, DF Wiemer

Index: Roussis, Vassilios; Wiemer, David F. Journal of Organic Chemistry, 1989 , vol. 54, # 3 p. 627 - 631

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Citation Number: 8

Abstract

In the presence of a Lewis acid, dialkyl phosphorochloridites react with a-hydroxy ketones to afford P-keto phosphonates and with a-hydroxy esters to afford phosphonic acid diesters. These reactions provide convenient access to a variety of structures, including P-keto phosphonates that are fully substituted at the a-carbon.

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