Tetrahedron

A simple and facile route for the synthesis of 2H-1, 4-benzoxazin-3-(4H)-ones via reductive cyclization of 2-(2-nitrophenoxy) acetonitrile adducts in the presence of Fe/ …

C Ramesh, BR Raju, V Kavala, CW Kuo, CF Yao

Index: Ramesh, Chintakunta; Raju, B. Rama; Kavala, Veerababurao; Kuo, Chun-Wei; Yao, Ching-Fa Tetrahedron, 2011 , vol. 67, # 6 p. 1187 - 1192

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Citation Number: 18

Abstract

A simple route for the synthesis of 1, 4-benzoxazin-3-(4H)-ones is described herein. This method involves the reductive cyclization of 2-(2-nitrophenoxy) acetonitrile adducts in the presence of Fe/acetic acid in good to excellent yields. This system was compatible with various other functional groups.