Tetrahedron

Synthesis of novel 3, 4-diaryl-5-aminopyrazoles as potential kinase inhibitors

LT Pierce, MM Cahill, FO McCarthy

Index: Pierce, Larry T.; Cahill, Michael M.; McCarthy, Florence O. Tetrahedron, 2011 , vol. 67, # 25 p. 4601 - 4611

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Citation Number: 10

Abstract

Abstract Synthesis of a diverse series of novel 3, 4-diaryl-5-aminopyrazoles as candidates in the development of new protein kinase inhibitors is reported for the first time. In the course of a wider study into bisindolylmaleimide (BIM) derivatives, we examined a novel 5- aminopyrazole heterocyclic moiety as a structural analogue of the highly potent VEGF-R2/3 inhibitor pyrrole-2-one (8). The versatile nature of this pharmacophore allows ...

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