Synlett

Improved synthetic route to C-ring ester-functionalized prodigiosenes

…, S Thirumalairajan, SM Crawford, TS Cameron…

Index: Uddin, Md. Imam; Thirumalairajan, Srinath; Crawford, Sarah M.; Cameron, T. Stanley; Thompson, Alison Synlett, 2010 , # 17 p. 2561 - 2564

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Citation Number: 12

Abstract

Abstract An efficient, optimized, and scalable process for the synthesis of C-ring ester- functionalized prodigiosenes has been developed by (i) exploiting a silylative Mukaiyama aldol strategy for the condensation of alkyl 5-formyl-2, 4-dimethylpyrrole-3-carboxylate and 4- methoxy-3-pyrrolin-2-one to form the corresponding ester-functionalized dipyrrinone analogues, and (ii) developing a facile synthesis of stable bromodipyrrin analogues for the ...