Synthetic and preliminary hemodynamic and whole animal toxicity studies on (R, S)-,(R)-, and (S)-2-methyl-3-(2, 4, 5-trihydroxyphenyl) alanine

…, KL Melmon, A Cheng, N Castagnoli Jr

Index: Musson; Karashima; Rubiero; Melmon; Cheng; Castagnoli Jr. Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1318 - 1323

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Citation Number: 8

Abstract

(6-OH-a-Me-Dopa) are reported. Hemodynamic studies in the rat have shown that this structural analogue and potential metabolite of the clinically useful drug (S)-a-Me-Dopa possesses weak hypotensive activity which resides in the R enantiomer. LDM studies in mice have established that 6-OH-a-Me-Dopa is over four times more toxic than a-Me-Dopa. Chronic exposure to 6-OH-a-Me-Dopa leads to renal and hepatic lesions. The ease of ...