Some new 2, 3, 6-trisubstituted quinazolinones as potent anti-inflammatory, analgesic and COX-II inhibitors

…, S Sharma, H Panwar, T Singh, VK Srivastava

Index: Kumar, Ashok; Sharma, Shalabh; Archana; Bajaj, Kiran; Sharma, Shipra; Panwar, Hemant; Singh, Tripti; Srivastava Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5293 - 5299

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Citation Number: 106

Abstract

Various 2-(substitutedphenylmethyleneimino) aminoacetylmethylene-3-(2′- substitutedindol-3′-yl)-halosubstituted-4 (3H) quinazolinones (5a–5i) and 2-(substituted phenylaminomethyleneacetyl-4′-oxo-1′-thiazolidinyl-3-(2 ″-substitutedindol-3 ″-yl) 4 (3H)-quinazolinones (6a–6i) have been synthesized in the present studies. The structure of these compounds have been elucidated by elemental (C, H, N) and spectral (IR, 1H NMR ...