The histamine H2-receptor agonist impromidine: synthesis and structure activity considerations

GJ Durant, CR Ganellin, DW Hills…

Index: Durant; Ganellin; Hills; et al. Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1414 - 1422

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Citation Number: 84

Abstract

Impromidine (1) is a potent and selective histamine Hz receptor agonist and its structure comprises a strongly basic guanidine group containing two different imidazole-containing side chains. In this paper we report the synthesis of analogues in which both of the side chains and the guanidine group are modified and tested as agonists or antagonists at histamine H, receptors on guinea pig atrium. A protonated amidine group linked by a ...