Three step vs one pot synthesis and X-ray crystallographic investigation of heptadentate triamide cyclen (1, 4, 7, 10-tetraazacyclododecane) based ligands and some …

…, JP Leonard, S Mulready, M Nieuwenhuyzen

Index: Gunnlaugsson, Thorfinnur; Leonard, Joseph P.; Mulready, Sinead; Nieuwenhuyzen, Mark Tetrahedron, 2004 , vol. 60, # 1 p. 105 - 113

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Citation Number: 35

Abstract

The synthesis of several lanthanide complexes from the tris alkylated cyclen (1, 4, 7, 10- tetraazacyclododecane) ligands and is described. The syntheses of and were investigated by means of two different synthetic routes (Method 1 and Method 2). The first of these involves the mono protection of cyclen using 4-methoxyphenylsulfonyl chloride, followed by alkylation of the remaining three secondary amines of cyclen, and deprotection using ...