Tetrahedron Letters

Catalytic monoalkylation of 1, 2-diols

T Maki, N Ushijima, Y Matsumura, O Onomura

Index: Maki, Toshihide; Ushijima, Nobuto; Matsumura, Yoshihiro; Onomura, Osamu Tetrahedron Letters, 2009 , vol. 50, # 13 p. 1466 - 1468

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Citation Number: 10

Abstract

A catalytic monoalkylation of 1, 2-diols by using a weak base has been developed. Copper (II) dichloride and boronic acids are effective catalysts for activating 1, 2-diols in the presence of potassium carbonate as a base. Various 1, 2-diols were selectively monoalkylated with allyl-, benzyl-and alkyl-halides in DMF by choosing a suitable catalyst for each 1, 2-diols.

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