Biaryls made easy: PEPPSI and the Kumada–Tamao–Corriu reaction
…, J Nasielski, CJ O'Brien, C Valente
Index: Organ, Michael G.; Abdel-Hadi, Mirvat; Avola, Stephanie; Hadei, Niloufar; Nasielski, Joanna; O'Brien, Christopher J.; Valente, Cory Chemistry - A European Journal, 2007 , vol. 13, # 1 p. 150 - 157
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Citation Number: 174
Abstract
Abstract An easily employed, highly versatile Kumada–Tamao–Corriu (KTC) protocol utilizing the PEPPSI (Pyridine, Enhanced, Precatalyst, Preparation, Stabilization and Initiation) precatalysts 1 and 2 is detailed. The ease-of-use of these catalysts and the synthesis of a wide range of hindered biaryls, large coupling partners and drug-like heterocycles, in high yield, makes the PEPPSI-KTC protocol very attractive. The high ...
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