Tetrahedron letters

An efficient route from coumarins to highly functionalized N-phenyl-2-quinolinones via Buchwald–Hartwig amination

T Ullrich, F Giraud

Index: Ullrich, Thomas; Giraud, Francis Tetrahedron Letters, 2003 , vol. 44, # 22 p. 4207 - 4211

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Citation Number: 16

Abstract

Multiple substituted N-phenyl-2-quinolinones were obtained in a convenient four-step route from a variety of commercially available coumarins, utilizing customised Buchwald–Hartwig amination protocols for the key reaction. Whereas simple aminolysis of coumarins is limited to non-electron-deficient, sterically unhindered derivatives of aniline under harsh conditions, the present method allows for conversions with multiple substituted aromatic amines, as ...