An efficient synthesis of novel N-acetyl-3-alkanoyl and 3-dienoyl tetramic acids

M Petroliagi, O Igglessi-Markopoulou

Index: Petroliagi, Margarita; Igglessi-Markopoulou, Olga Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 23 p. 3543 - 3548

Full Text: HTML

Citation Number: 6

Abstract

A general synthesis of N-acetyl-3-alkanoyl-and 3-dienoyl-tetramic acids is presented. The condensation of N-(N-acetylglycyloxy) succinimide with β-keto esters bearing alkanoyl or dienoyl groups furnishes the new 3-substituted N-acetyltetramic acids 6–9 and 16 in good yields. The key intermediates 4 and 5 have been isolated and subsequently cyclized to the corresponding tetramic acids. Spectral data for and the physical characteristics of all ...

Related Articles:

Synthesis of 4-Alkyl-and 4-(ω-Chloroalkyl)-3-hydroxy-5-alkylidenebutenolides Based On Cyclizations of 4-Alkyl-and 4-(ω-Chloroalkyl)-1, 3-bis (trimethylsilyloxy) buta- …

[Nguyen, Van Thi Hong; Bellur, Esen; Appel, Bettina; Langer, Peter Synthesis, 2006 , # 17 p. 2865 - 2872]

Discrimination of β??Ketoesters by Ruthenium (II)–Binap??Catalyzed Asymmetric Hydrogenation

[Kramer, Rainer; Brueckner, Reinhard Angewandte Chemie - International Edition, 2007 , vol. 46, # 34 p. 6537 - 6541]

Synthesis of novel β-lactone inhibitors of fatty acid synthase

[Richardson, Robyn D.; Knowles, Lynn M.; Cieplak, Piotr; Smith, Jeffrey W.; Ma, Gil; Oyola, Yatsandra; Zancanella, Manuel; Romo, Daniel Journal of Medicinal Chemistry, 2008 , vol. 51, # 17 p. 5285 - 5296]

Continuous flow synthesis of toxic ethyl diazoacetate for utilization in an integrated microfluidic system

[Maurya, Ram Awatar; Min, Kyoung-Ik; Kim, Dong-Pyo Green Chemistry, 2014 , vol. 16, # 1 p. 116 - 120]

Ant venom alkaloids from Monomorium species: natural insecticides

[Bacos; Basselier; Celerier; Lange; Marx; Lhommet; Escoubas; Lemaire; Clement Tetrahedron Letters, 1988 , vol. 29, # 25 p. 3061 - 3064]

More Articles...