Bioorganic chemistry

Synthesis and antibacterial activity of novel enolphosphate derivatives

C Grison, N Barthes, C Finance, RE Duval

Index: Grison, Claude; Barthes, Nicolas; Finance, Chantal; Duval, Raphael E. Bioorganic Chemistry, 2010 , vol. 38, # 5 p. 218 - 223

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Citation Number: 5

Abstract

A new class of enolphosphates derivatives, the 1-alkenyldiphosphates, was designed and a rapid and efficient synthesis for these compounds was developed. These new molecules showed interesting in vitro antibacterial activities (MIC) against Gram-positive bacteria (Staphylococcus aureus) and Gram-negative pathogens including Pseudomonas aeruginosa and Escherichia coli.