Structure-activity relationships of antibacterial 6, 7-and 7, 8-disubstituted 1-alkyl-1, 4-dihydro-4-oxoquinoline-3-carboxylic acids

…, A Itoh, S Murayama, S Suzue, T Irikura

Index: Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363

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Citation Number: 546

Abstract

Previous quantitative and qualitative structure-activity studies in antibacterial monosubstituted l-ethyl-1, 4-di-hydro-4-oxoquinoline-3-carboxylic acids prompted us to synthesize the 6, 7, 8-polysubstituted compounds. In this paper, the preparation and antibacterial activity of the 6, 7-and 7, 8-disubstituted compounds and their derivatives are described. Among these compounds, l-ethyl-6-fluoro-1, 4-dihydro-4-oxo-7-(l-piperazinyl) ...