Ligation and reduction of iron (III) porphyrins by amines. A model for cytochrome P-450 monoamine oxidase

CE Castro, M Jamin, W Yokoyama…

Index: Castro, C. E.; Jamin, Mary; Yokoyama, W.; Wade, Ruth Journal of the American Chemical Society, 1986 , vol. 108, # 14 p. 4179 - 4187

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Citation Number: 54

Abstract

Abstract: The scope and mechanism of the ligation and reduction of iron (II1) porphyrins by amines are presented. The reaction is general and proceeds with the overall stoichiometry 2PFe"'CI+ 5RNH2-2PFe"(H2NR),+ R'CH= NH+ 2RNH3+ C1-. Imines are the only amine- derived products. The ability of the amine to coordinate iron and its possession of a XHNH moiety are essential for reduction. The reaction path entails two successive reversible ...