… )??2??cyanoacetate (Boc??Oxyma) as Coupling Reagent for Racemization??Free Esterification, Thioesterification, Amidation and Peptide Synthesis

…, MP Chakravarty, A Paul, B Mandal

Index: Thalluri, Kishore; Nadimpally, Krishna Chaitanya; Chakravarty, Maharishi Parasar; Paul, Ashim; Mandal, Bhubaneswar Advanced Synthesis and Catalysis, 2013 , vol. 355, # 2-3 p. 448 - 462

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Citation Number: 10

Abstract

Abstract Here we report the synthesis and utility of ethyl 2-(tert-butoxycarbonyloxyimino)-2- cyanoacetate (Boc-Oxyma) as an efficient coupling reagent for racemization-free esterification, thioesterification, amidation reactions and peptide synthesis that uses equimolar amounts of acids and alcohols, thiols, amines or amino acids, respectively. Its application to solid phase as well as solution phase peptide synthesis is also ...

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