1, 4–Diarylpiperazines and analogs as anti-tubercular agents: Synthesis and biological evaluation

…, D Cappoen, J Laurent, D Stanicki, A Mayence…

Index: Forge; Cappoen; Laurent; Stanicki; Mayence; Huang; Verschaeve; Huygen; Vanden Eynde European Journal of Medicinal Chemistry, 2012 , vol. 49, p. 95 - 101

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Citation Number: 15

Abstract

Despite progress in modern chemotherapy to combat tuberculosis, the causative pathogen Mycobacterium tuberculosis (M. tb.) is far from eradicated. Bacillary resistance to anti- mycobacterial agents, bacillary persistence and human immunodeficiency virus (HIV) co- infection hamper current drug treatment to completely cure the infection, generating a constant demand for novel drug candidates to tackle these problems. A small library of ...

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