Investigating Direct Access to 2??Oxospiro [4.5] decanones via 6π??Electrocyclisation

…, H Schill, CM Williams, PV Bernhardt

Index: Pouwer, Rebecca H.; Schill, Heiko; Williams, Craig M.; Bernhardt, Paul V. European Journal of Organic Chemistry, 2007 , # 28 p. 4699 - 4705

Full Text: HTML

Citation Number: 11

Abstract

Abstract The 2-oxospiro [4.5] decan-1-one (or spiro-γ-lactone) structural motif is contained within a number of natural products, for example, the clerodane family of diterpenes. Methods to construct this structural motif are somewhat limited and usually involve multiple functional group interconversions. A novel synthetic approach to this system utilising 6π- electrocyclisation has been identified and associated density functional calculations ...

Related Articles:

Desymmetrisation of 4, 4-disubstituted cyclohexanones by enzyme-catalysed resolution of their enol acetates

[Allan, Graham; Carnell, Andrew J.; Hernandez, Maria Luisa Escudero; Pettman, Alan Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 20 p. 3382 - 3388]

1-Chloroalkyl p-tolyl sulfoxides as acetylide anion equivalent: a novel synthesis including asymmetric synthesis of propargylic alcohols from carbonyl compounds

[Satoh, Tsuyoshi; Hayashi, Yasumasa; Yamakawa, Koji Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 7 p. 2153 - 2158]

Copper??Catalyzed Borylative Allyl–Allyl Coupling Reaction

[Semba, Kazuhiko; Fujihara, Tetsuaki; Terao, Jun; Tsuji, Yasushi Angewandte Chemie - International Edition, 2013 , vol. 52, # 47 p. 12400 - 12403 Angew. Chem., 2013 , vol. 125, # 47 p. 12626 - 12629,4]

Synthesis of SB 222618. A potential PDE IV inhibitor

[Conde, Jose J.; Mendelson, Wilford Tetrahedron Letters, 2000 , vol. 41, # 6 p. 811 - 814]

More Articles...