The conjugation of nonsteroidal anti-inflammatory drugs (NSAID) to small peptides for generating multifunctional supramolecular nanofibers/hydrogels

J Li, Y Kuang, J Shi, Y Gao, J Zhou…

Index: Li, Jiayang; Kuang, Yi; Shi, Junfeng; Gao, Yuan; Zhou, Jie; Xu, Bing Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 908 - 917

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Citation Number: 29

Abstract

Abstract Here we report supramolecular hydrogelators made of nonsteroidal anti- inflammatory drugs (NSAID) and small peptides. The covalent linkage of Phe–Phe and NSAIDs results in conjugates that self-assemble in water to form molecular nanofibers as the matrices of hydrogels. When the NSAID is naproxen (1), the resultant hydrogelator 1a forms a hydrogel at a critical concentration (cgc) of 0.2 wt% at pH 7.0. Hydrogelator 1a, also ...