Preorganized macrocyclic ligands: a novel approach to functionalized hemispherands via aromatization

…, M Skowronska-Ptasinska, DN Reinhoudt…

Index: Dijkstra, Pieter J.; Skowronska-Ptasinska, Maria; Reinhoudt, David N.; Hertog, Herman J. den; Eerden, Johan van; et al. Journal of Organic Chemistry, 1987 , vol. 52, # 22 p. 4913 - 4921

Full Text: HTML

Citation Number: 18

Abstract

Reaction of the 1, 3-diaryl-2-propanone moiety in the flexible 18-membered macrocycle 2b with nitromalonodialdehyde to yield the hemispherand If represents a novel method for the synthesis of partly preorganized macrocyclic ligands. The 0-0 repulsion in the macrocyclic cavity is compensated for by the energetically favorable formation of an aromatic ring. The macrocycle 2b was synthesized in five steps from 3a. The carbonyl group of 3a was ...

Related Articles:

Design and synthesis of new naphthalenic derivatives as ligands for 2-[125I] iodomelatonin binding sites

[Langlois, Michel; Bremont, Beatrice; Shen, Shuren; Poncet, Annie; Andrieux, Jean; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2050 - 2060]

Design and synthesis of new naphthalenic derivatives as ligands for 2-[125I] iodomelatonin binding sites

[Langlois, Michel; Bremont, Beatrice; Shen, Shuren; Poncet, Annie; Andrieux, Jean; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2050 - 2060]

Design and synthesis of new naphthalenic derivatives as ligands for 2-[125I] iodomelatonin binding sites

[Langlois, Michel; Bremont, Beatrice; Shen, Shuren; Poncet, Annie; Andrieux, Jean; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2050 - 2060]

The reaction of various methoxy-substituted haloarenes with amines and nitriles under aryne-forming conditions

[Razzuk, Aziz; Biehl, Edward R. Journal of Organic Chemistry, 1987 , vol. 52, # 12 p. 2619 - 2622]

More Articles...