Transferring oxygen isotopes to 1, 2, 4-benzotriazine 1-oxides forming the corresponding 1, 4-dioxides by using the HOF· CH 3 CN complex
J Gatenyo, K Johnson, A Rajapakse, KS Gates…
Index: Gatenyo, Julia; Johnson, Kevin; Rajapakse, Anuruddha; Gates, Kent S.; Rozen, Shlomo Tetrahedron, 2012 , vol. 68, # 43 p. 8942 - 8944
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Abstract
Heterocyclic benzotriazine N-oxides are an interesting class of experimental anticancer and antibacterial agents. Analogs with 18O incorporated into the N-oxide group may offer useful mechanistic tools. We describe the use of H218OF· CH3CN in a fast, readily executed and high-yielding preparation of 1, 2, 4-benzotriazine 1, 4-dioxides containing an 18O-label at the 4-oxide position.
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