Efficient methods for the preparation of acetylenic ketones

HD Verkruijsse, YA Heus-Kloos, L Brandsma

Index: Verkruijsse, H. D.; Heus-Kloos, Y. A.; Brandsma, I. Journal of Organometallic Chemistry, 1988 , vol. 338, p. 289 - 294

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Citation Number: 38

Abstract

Abstract A number of acetylenic ketones RC CC ( O) R′ have been obtained in good yields from lithiated acetylenes RC CLi and acetic anhydride, N, N-dimethylacetamide, or N, N-dimethylbenzamide. The most convenient and general method consists of treating alkynylzinc chlorides with acid halides R′ C ( O) Cl. Benzoyl chloride (R′= Ph), acryloyl chloride (R′= CH 2 CH), and butynoyl chloride (R′= C 2 H 5 C C) react only in the ...