The Journal of Organic Chemistry

Conformational studies of N, N-disubstituted nicotinamides. NMR peak assignments and utilization of shift reagents with 2, 6-dichloronicotinamides

GR Newkome, T Kawato

Index: Newkome, George R.; Kawato, Toshio Journal of Organic Chemistry, 1980 , vol. 45, # 4 p. 629 - 632

Full Text: HTML

Citation Number: 5

Abstract

Europium-induced shift studies are reported for numerous substituted nicotinamides. Without ring substituents, the europium ion interacts with both the pyridine nitrogen and the amide oxygen; however, with 2, 6 ring substituents interaction with the amide oxygen is favored. Simple correlations for the induced shifts of the pyridine ring hydrogens tire presented and are useful in the conformational analysis of nicotinamides. A combination ...