Lithium iodide-promoted aldol condensation reactions

RG Kelleher, MA McKervey, P Vibuljan

Index: Kelleher, Roger G.; McKervey, M. Anthony; Vibuljan, Pongsak Journal of the Chemical Society, Chemical Communications, 1980 , # 11 p. 486 - 488

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Citation Number: 10

Abstract

Anhydrous lithium iodide in ether, tetrahydrofuran, or benzene is an effective reagent for the formation of αβ-unsaturated ketones by condensation of alkyl ketones with enolisable and non-enolisable aldehydes; in the presence of trimethylchlorosilane–triethylamine enone formation is suppressed and high yields of 1, 3-hydroxy-ketones are obtained as their trimethylsilyl ether derivatives.

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