Tetrahedron Letters

Synthesis of germanium derivatives of uracil and 5-fluorouracil

K Takakusaki, N Kakimoto, Y Takeuchi, S Tomoda

Index: Takakusaki, Katsumi; Kakimoto, Norihiro; Takeuchi, Yoshito; Tomoda, Shuji Tetrahedron Letters, 1983 , vol. 24, # 16 p. 1707 - 1710

Full Text: HTML

Citation Number: 14

Abstract

Abstract N, N-Diacetate of uracil and 5-fluorouracil reacted with trichlorogermane to afford the Michael addition products, 1H, 5H, 6H-3-acetyl-6-trichlorogermylpyrimidine-2, 4-dione and 1H, 5H, 6H-3-acetyl-5-fluoro-6-trichlorogermylpyrimidine-2, 4-dione, respectively, which were hydrolyzed to the corresponding deacetylated germanium sesquioxides.