Journal of medicinal chemistry

Synthesis of some 5-phenylhexahydroazepino [4, 5-b] indoles as potential neuroleptic agents

AJ Elliott, EH Gold, H Guzik

Index: Elliott, Arthur J.; Gold, Elijah H.; Guzik, Henry Journal of Medicinal Chemistry, 1980 , vol. 23, # 11 p. 1268 - 1269

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Citation Number: 9

Abstract

Discussion None of the compounds was active in the MAT, writhing, or pentylenetetrazole tests (EDso> 30 mg/kg). The lack of activity in MAT at this high dose makes it unlikely that any of the compounds tested have significant neuroleptic activity. All presently useful neuroleptic agents would have shown complete protection at the screening dose. For example, chloropromazine has an EDw of 0.3 mg/kg. Interestingly, several of the ...