Analogs of 1, 5-bis (4-amidinophenoxy) pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia

…, JD Geratz, KA Ohemeng, M Cory, JE Hall

Index: Tidwell; Jones; Geratz; Ohemeng; Cory; Hall Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1252 - 1257

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Citation Number: 141

Abstract

A series of 33 analogues of the anti-Pneumocystis carinii drug 1, 5-bis (4-amidinophenoxy) pentane (pentamidine) was synthesized for screening against a rat model of P. carinii pneumonia (PCP). Twenty-five of the compounds showed efficacy against PCP when compared to a saline-treated control group. Two compounds, 1, 4-bis (4-amidinophen0xy) butane (butamidine, 6) and 1, 3-bis (4-amidino-2-methoxyphenoxy) propane (DAMP, 16), ...