Modular Synthesis of Triazole??Containing Triaryl α??Helix Mimetics

I Ehlers, P Maity, J Aubé, B König

Index: Ehlers, Ina; Maity, Prantik; Aube, Jeffrey; Koenig, Burkhard European Journal of Organic Chemistry, 2011 , # 13 p. 2474 - 2490

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Citation Number: 14

Abstract

Abstract We describe novel scaffold designs for nonpeptidic α-helix mimetics. The tricyclic scaffolds contain triazoles and reproduce amino acid side chains i, i+ 3, and i+ 7. The three different scaffolds are synthetically readily accessible, allow the introduction of further substituents to increase the versatility, and are suitable for library design. A modular synthesis route using Cu I-and Ru II-catalyzed azide–alkyne [3+ 2] cycloadditions as ...