Journal of heterocyclic chemistry

Convenient preparative methods for N??aryl?螃摸?pyridones from γ??pyrones

JH Looker, MD Cliffton

Index: Looker, James H.; Cliffton, Michael D. Journal of Heterocyclic Chemistry, 1986 , vol. 23, p. 5 - 8

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Citation Number: 5

Abstract

Abstract 2-Hydroxymethyl-5-methoxy-4-H-pyran-4-one (1) reacts with aniline and six aniline derivatives in very dilute aqueous hydrochloric acid at reflux temperature to give the N-aryl-γ- pyridone. A second procedure utilizes the aromatic amine hydrochloride by reacting it with 1 in aqueous medium at reflux temperature. pN itroaniline hydrochloride and 1 give the N-aryl- γ-pyridone in 65% yield, as opposed to 12% from the dilute acid procedure.