Chemical Communications

An oxidative cross-dehydrogenative-coupling reaction in water using molecular oxygen as the oxidant: vanadium catalyzed indolation of tetrahydroisoquinolines

K Alagiri, GSR Kumara, KR Prabhu

Index: Alagiri, Kaliyamoorthy; Kumara, Guralamatta Siddappa Ravi; Prabhu, Kandikere Ramaiah Chemical Communications, 2011 , vol. 47, # 42 p. 11787 - 11789

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Citation Number: 47

Abstract

An aerobic oxidative cross-dehydrogenative coupling reaction between sp3 C–H and sp2 C– H bonds is developed by employing a vanadium catalyst (10 mol%) in an aqueous medium using molecular oxygen as the oxidant. This environmentally benign strategy exhibits larger substrate scope and shows high regioselectivity.

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