A new approach to methoxyisatins leading to the total synthesis of ophiuroidine and other hydroxytryptanthrins

JJ Mason, T Janosik, J Bergman

Index: Mason, Jeffrey J.; Janosik, Tomasz; Bergman, Jan Synthesis, 2009 , # 21 p. 3642 - 3648

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Citation Number: 10

Abstract

Abstract A new method for the preparation of methoxyisatins from the corresponding methoxyanilines is described. The resulting methoxyisatins were used in the syntheses of several methoxytryptanthrin compounds. The natural product ophiuroidine (4, 8, 9- trihydroxytryptanthrin) was obtained from the appropriate trimethoxy precursor using a microwave-mediated Prey demethylation.