Knoevenagel condensation of diethylmalonate with aldehydes catalyzed by immobilized bovine serum albumin (BSA)

P Ramesh, B Shalini, NW Fadnavis

Index: Ramesh, Perla; Shalini, Basetty; Fadnavis, Nitin W. RSC Advances, 2014 , vol. 4, # 15 p. 7368 - 7373

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Citation Number: 9

Abstract

Knoevenagel condensation between aldehydes and diethylmalonate is catalyzed efficiently by bovine serum albumin (BSA) immobilized covalently on an epoxy-functionalized polymeric support, Immobead IB-350. The reaction is carried out conveniently at room temperature in DMSO in which aliphatic, heterocyclic and aromatic aldehydes react efficiently. After extraction with heptane and treatment with Candida antarctica lipase CAL ...