Synthesis of N-[(3-substituted phenoxy) alkyl] acetohydroxamic acids, potential inhibitors of the enzyme 5-lipoxygenase

J Svoboda, J Paleček

Index: Svoboda, Jiri; Palecek, Jaroslav Collection of Czechoslovak Chemical Communications, 1991 , vol. 56, # 6 p. 1317 - 1332

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Citation Number: 4

Abstract

Abstract The synthesis of the title compounds starts from methyl (3-subst. phenoxy) alkanoates II which are reduced to the corresponding aldehydes and then transformed to oximes V by reaction with hydroxylamine. Reduction with borane-pyridine complex gives the hydroxylamines VI which on diacetylation and partial deacetylation provide the hydroxamic acids VIII.