Fast microwave promoted palladium-catalyzed synthesis of phthalides from bromobenzyl alcohols utilizing DMF and Mo (CO) 6 as carbon monoxide sources

X Wu, AK Mahalingam, Y Wan, M Alterman

Index: Wu, Xiongyu; Mahalingam; Wan, Yiqian; Alterman, Mathias Tetrahedron Letters, 2004 , vol. 45, # 24 p. 4635 - 4638

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Citation Number: 58

Abstract

A fast method utilizing in situ generated CO for the synthesis of phthalides has been developed. DMF and Mo (CO) 6 were applied as two alternative CO-sources in these microwave promoted carbonylation–lactone formation reactions. Mo (CO) 6 was found to be the more generally applicable CO-source and provided phthalides as well as dihydroisocoumarin, dihydroisoindone, and phthalimide from the corresponding aryl ...