Amidoalkylating Properties of 1-(N-Acylamino) Alkyltriphenylphosphonium Salts

…, J Adamek, R Mazurkiewicz, K Zielińska

Index: Pazdzierniok-Holewa, Agnieszka; Adamek, Jakub; Mazurkiewicz, Roman; Zielinska, Katarzyna Phosphorus, Sulfur and Silicon and the Related Elements, 2013 , vol. 188, # 1-3 p. 205 - 212

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Abstract

Easily accessible 1-(N-acylamino)alkyltriphenylphosphonium salts react smoothly with nitrogen, sulfur, phosphorus and oxygen nucleophiles in the presence of (i-Pr) 2 EtN to give the expected α-amidoalkylation products, usually in good or very good yields. α-Amidoalkylation of dialkyl malonates or acetylacetates requires the application of a much stronger base (DBU) and gives the best results under the influence of microwave irradiation. α- ...

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