N??ethoxycarbonylamidines as starting materials and intermediates in the synthesis of heterocyclic compounds

WD Dean, EP Papadopoulos

Index: Dean, W. D.; Papadopoulos, E. P. Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 171 - 176

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Citation Number: 15

Abstract

Abstract Treatment of N-ethoxycarbonylthioamides (1) with primary aromatic amines yields N-aryl-N′-ethoxy-carbonylamidines (2), which thermally cyclize to 2-aryl-4 (3H)- quinazolinones (6). Analogous reactions of 1 with ethyl 3-aminocrotonate and with 2-amino- 2-thiazoline lead respectively to ethyl 2-aryl-3, 4-dihydro-6-methyl-4-oxo-5- pyrimidinecarboxylates (10) and to 2-aryl-6, 7-dihydro-4H-thiazolo [3, 2-a]-1, 3, 5-triazin-4- ...

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