Synthesis of sulfur analogues of cyclic phospholipid conjugated with N1-(2-furanidyl)-N3-(2-hydroxyethyl)-5-fluorouracil

C Zhang, R Chen, C Tang, Z Zhang

Index: Zhang, Chengxiang; Chen, Ruyu; Tang, Chuchi; Zhang, Zhongbiao Phosphorus, Sulfur and Silicon and Related Elements, 1998 , vol. 132, p. 155 - 161

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Citation Number: 8

Abstract

Abstract Two types of cyclic polythiophospholipid conjugated with N1-(2-fu ran idyl)-N3-(2- hydroxyethyl)-5-fluorouracil were synthesized. The hexaethyl phosphorous triamide, activated by a catalytic amount of iodine, was used as the phosphorylating reagent in a one- pot reaction resulting in a number of novel phospholipid-drug conjugates.