Covalent analogues of DNA base-pairs and triplets. Part 3: Synthesis of 1, 4-and 1, 3-bis (purin-6-yl) benzenes and 1-(1, 3-dimethyluracil-5-yl)-3 or 4-(purin-9-yl) …

M Havelková, D Dvořák, M Hocek

Index: Havelkova, Martina; Dvorak, Dalimil; Hocek, Michal Tetrahedron, 2002 , vol. 58, # 37 p. 7431 - 7435

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Citation Number: 25

Abstract

The Stille cross-coupling reactions of 1, 4-and 1, 3-bis (trialkylstannyl) benzenes 2 or 3 with 9-benzyl-6-chloropurine (1) led either to mono-coupled 4-or 3-[(tributylstannyl) phenyl] benzenes 5a and 5b or to bis (9-benzylpurin-6-yl) benzenes (4a or 4b) depending on the ratio of the starting compounds, nature of the stannane and conditions. Analogous reaction of 1 with benzene-1, 4-diboronic acid gave selectively 4a in good yield. The reaction of ...