A facile route for the synthesis of vinyl-substituted 1, 3, 4-oxadiazoles

SP Pardeshi, SS Patil, AA Patil, VD Bobade

Index: Pardeshi, Santosh P.; Patil, Sachin S.; Patil, Amar A.; Bobade, Vivek D. Research on Chemical Intermediates, 2013 , vol. 39, # 7 p. 3399 - 3405

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Abstract

Abstract An efficient synthesis of vinyl-substituted 1, 3, 4-oxadiazoles using o-nitrophenyl sulfoxide precursor via syn-elimination reaction using sodium acetate in THF is described. This method is cost effective as it uses cheap o-nitrothiophenol and can be used in the synthesis of vinyl intermediates during synthesis of bioactive compounds, which avoids the use of any toxic metals.

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