Synlett

Enantioselective Synthesis of (R)-α-Alkylhomoserines and (R)-α-Alkylhomocysteines via Phase-Transfer Catalytic Alkylation

TS Kim, YJ Lee, K Lee, BS Jeong, H Park, S Jew

Index: Kim, Taek-Soo; Lee, Yeon-Ju; Lee, Kyoungyim; Jeong, Byeong-Seon; Park, Hyeung-Geun; Jew, Sang-Sup Synlett, 2009 , # 4 p. 671 - 674

Full Text: HTML

Citation Number: 0

Abstract

Abstract Efficient enantioselective synthetic methods for (R)-α-alkylhomoserines and (R)-α- alkylhomocysteines have been developed. The phase-transfer catalytic alkylation of 2- phenyl-5, 6-dihydro-4H-1, 3-oxazine-4-carboxylic acid tert-butyl ester and 2-phenyl-5, 6- dihydro-4H-1, 3-thiazine-4-carboxylic acid tert-butyl ester, in the presence of N-2′, 3′, 4′- trifluorobenzylcinchonidinium bromide, gave the corresponding alkylated products, which ...