Synthesis and cytotoxicity on human leukemia cells of furonaphthoquinones isolated from tabebuia plants

R Inagaki, M Ninomiya, K Tanaka, K Watanabe…

Index: Inagaki, Ryuta; Ninomiya, Masayuki; Tanaka, Kaori; Watanabe, Kunitomo; Koketsu, Mamoru Chemical and Pharmaceutical Bulletin, 2013 , vol. 61, # 6 p. 670 - 673

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Citation Number: 8

Abstract

Furonaphthoquinones are promising skeletons for anticancer drug molecules. In particular, methoxylated furonaphthoquinones are characteristic constituents of Tabebuia plants. In this research, we synthesized the furonaphthoquinones by effective one-pot cascade reactions of 3-phenyliodonio-1, 2, 4-trioxo-1, 2, 3, 4-tetrahydronaphthalenides with 3-butyn-2-ol in the presence of palladium and cuprous catalysts via Sonogashira coupling and ...

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