Synthesis and antitumor activity of bithienyl-pyrimidine derivatives with electrostatic binding side chains

YM Chou, MC Lai, TM Hwang, CW Ong

Index: Chou, Yi-Meen; Lai, Ming Chih; Hwang, Tsai-Mian; Ong, Chi Wi Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 18 p. 2643 - 2646

Full Text: HTML

Citation Number: 4

Abstract

A series of bithienyl-pyrimidines having cationic side chain have been developed as antitumor agents. This work illustrates the overwhelming importance of the bithienyl unit for efficient DNA binding. The X-ray structure of 4-(2′, 2 ″-thien-5-yl)-2-chloropyrimidine was obtained for postulating the conformation of the bithienyl-pyrimidine moiety.

Related Articles:

De novo design of nonpeptidic compounds targeting the interactions between interferon-α and its cognate cell surface receptor

[Bello, Angelica M.; Bende, Tanushree; Wei, Lianhu; Wang, Xiaoyang; Majchrzak-Kita, Beata; Fish, Eleanor N.; Kotra, Lakshmi P. Journal of Medicinal Chemistry, 2008 , vol. 51, # 9 p. 2734 - 2743]

Molecular basis for bleomycin amplification: conformational and stereoelectronic effects in unfused amplifiers

[Strekowski, Lucjan; Mokrosz, Jerzy L.; Tanious, Farial A.; Watson, Rebecca A.; Harden, Donald; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1231 - 1240]

More Articles...