The Efficient Synthesis of FMOC-L-Homoglutamine

K Wiśniewski, AS Kolodziejczyk

Index: Wisniewski, Kazimierz; Kolodziejczyk, Aleksandra S. Organic Preparations and Procedures International, 1997 , vol. 29, # 3 p. 338 - 341

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Abstract

The oxidation of E-methylene unit in lysine derivatives is well-known.'-'We employed the method of oxidation with permanganate in aqueous solution elaborated by Kasprzykowska and Liberek5 to accomplish the first step of the synthesis. Since the N-acylamide group present in the oxidation product is susceptible to both basic and acidic hydrolysis leading to dicarboxy amino acid and benzyl carbamate, 8 the introduction of Fmoc was carried out ...