Synlett

Heteroannulation of 3-Bis (methylthio) acrolein with Aromatic Amines-A Convenient Highly Regioselective Synthesis of 2-(Methylthio) quinolines and their Benzo/ …

K Panda, I Siddiqui, PK Mahata, H Ila, H Junjappa

Index: Panda, Kausik; Siddiqui, Iffat; Mahata, Pranab K.; Ila, Hiriyakkanavar; Junjappa, Hiriyakkanavar Synlett, 2004 , # 3 p. 449 - 452

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Citation Number: 18

Abstract

Abstract A simple and efficient synthesis of 2-(methylthio) quinolines and their condensed analogs has been developed through acid-induced cyclocondensation of their respective anilines or aromatic diamines with 3-bis (methylthio) acrolein. The 2-(methylthio) functionality in these quinolines could be either dethiomethylated or replaced by various nitrogen and carbon nucleophiles to afford 2-substituted quinolines.

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