Studies on v-triazoles. 9. Antiallergic 4, 9-dihydro-4, 9-dioxo-1H-naphtho [2, 3-d]-v-triazoles

DR Buckle, H Smith, BA Spicer…

Index: Buckle; Smith; Spicer; Tedder Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 714 - 719

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Citation Number: 10

Abstract

12, R,(R,)= Me; 14, R,= R,= H 15, R,= Me; R,= H 16, R,= R,= Me Rz (Ri)= H 13, R,= R,= Me choice being largely dependent on the position and type of substitution. The parent compound, 14, was prepared from 2, 3-dichloronaphthoquinone by the method of Fieser and Martin: and an analogous procedure was used for the 6-methyl and 6, 7-dimethyl homologues, 15 and 16, respectively. Thus, bromination of the naphthoquinones 4 and 5 ( ...